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Phenotype Image Detail
Caption Representative photomicrographs (A-F) of H & E stained sections of eyes from 2 month old Cdkn2atm1Cjs/Cdkn2atm1Cjs (A & D), Trp53tm1Tyj/Trp53tm1Tyj (B & E), and Cdkn2atm1Cjs/Cdkn2atm1Cjs Trp53tm1Tyj/Trp53tm1Tyj (C & F) mice. D-F: Higher magnification of retrolental tissue from corresponding section in A-C. Note the presence of pigmented retrolental tissue ( A & C) and posterior lens capsule destruction and repair ( arrowheads in D & F) in Cdkn2atm1Cjs homozygous and double homozygous mouse eyes, whereas minimal retrolental tissue is present (arrow, B) and the posterior lens is intact (E) in the Trp53tm1Tyj homozygous mouse eye. Neither retrolental tissue nor lens capsule disruption was observed in age-matched wild type mice. Magnifications: A-C: x40; D-F: x400 Scale bar: A: 250um
Copyright This image is from McKeller RN, Proc Natl Acad Sci U S A 2002 Mar 19;99(6):3848-53. Copyright 2002 National Academy of Sciences, U.S.A. J:75215
Symbol Name
Cdkn2atm1Cjs cyclin dependent kinase inhibitor 2A; targeted mutation 1, Charles J Scherr
Trp53tm1Tyj transformation related protein 53; targeted mutation 1, Tyler Jacks
Allelic Composition Genetic Background
Cdkn2atm1Cjs/Cdkn2atm1Cjs involves: 129X1/SvJ * C57BL/6
involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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