Phenotypes Associated with This Genotype

Genotype
MGI:3692946

• Allelic Composition: Tg(Tnfsf13b)1Fma/0; Tnfsf14^tm1Kpf/Tnfsf14^tm1Kpf
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

increased B cell number ( J:114782 )

• a marked increase in some B cell subsets compared to wild-type is detected in 12 week old mice

increased plasma cell number ( J:114782 )

• there is an increased frequency of B220^neg/lo, IgA+ plasma cells in lamina propria preparations

abnormal spleen germinal center morphology ( J:114782 )

• numerous germinal centers are observed in B cell follicles of mutants

abnormal spleen marginal zone morphology ( J:114782 )

• splenic marginal zone is increased in size

increased IgA level ( J:114782 )

• augmented IgA staining is found in lamina propria of mutants

renal/urinary system

abnormal mesangial cell morphology ( J:114782 )

• in 8-month old mice, some thickening of mesangial and basement membranes

renal glomerular immunoglobulin deposits ( J:114782 )

• deposition of IgA in nearly all glomeruli is detected, similar to Tnfsf14-sufficient transgenic mice

immune system

increased B cell number ( J:114782 )

• a marked increase in some B cell subsets compared to wild-type is detected in 12 week old mice

increased plasma cell number ( J:114782 )

• there is an increased frequency of B220^neg/lo, IgA+ plasma cells in lamina propria preparations

abnormal spleen germinal center morphology ( J:114782 )

• numerous germinal centers are observed in B cell follicles of mutants

abnormal spleen marginal zone morphology ( J:114782 )

• splenic marginal zone is increased in size

increased IgA level ( J:114782 )

• augmented IgA staining is found in lamina propria of mutants

cellular

abnormal mesangial cell morphology ( J:114782 )

• in 8-month old mice, some thickening of mesangial and basement membranes