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Phenotypes Associated with This Genotype
Genotype
MGI:3690553
Allelic
Composition		 Cd19tm1(cre)Cgn/Cd19+
Faslpr/Fastm1Cgn
Tg(Cd4-cre)1Cwi/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * MRL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (12 available); any Cd19 mutation (57 available)
Faslpr mutation (39 available); any Fas mutation (83 available)
Fastm1Cgn mutation (1 available); any Fas mutation (83 available)
Tg(Cd4-cre)1Cwi mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
enlarged spleen ( J:114948 )
• similar to mice with recombination only in T cells
increased double-negative T cell number ( J:114948 )
• similar to mice with recombination only in T cells
enlarged lymph nodes ( J:114948 )
• similar to mice with recombination only in T cells

hematopoietic system
enlarged spleen ( J:114948 )
• similar to mice with recombination only in T cells
increased double-negative T cell number ( J:114948 )
• similar to mice with recombination only in T cells

growth/size/body
enlarged spleen ( J:114948 )
• similar to mice with recombination only in T cells

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory