Phenotypes Associated with This Genotype

Genotype
MGI:3689909

• Allelic Composition: Del(2Hoxd1-Hoxd10)26Ddu/Del(2Hoxd1-Hoxd10)26Ddu
• Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality ( J:91567 )

limbs/digits/tail

abnormal autopod morphology ( J:91567 )

• loss of anterior posterior asymmetry and ectopic Hoxd13 and Hoxd11 expression

abnormal carpal bone morphology ( J:91567 )

• perfectly symetrical carpus

abnormal pollex morphology ( J:91567 )

• elongation of the thumb on the forelimbs

abnormal radius morphology ( J:91567 )

• the distal radius has the morphology of the distal ulna

abnormal limb development ( J:91567 )

• bilateral symmetry occurs in 8 of 8 right forelimbs but less frequently in left forelimbs

small limb buds ( J:91567 )

• reduced initial size

skeleton

abnormal carpal bone morphology ( J:91567 )

• perfectly symetrical carpus

abnormal radius morphology ( J:91567 )

• the distal radius has the morphology of the distal ulna

embryo

small limb buds ( J:91567 )

• reduced initial size