Phenotypes Associated with This Genotype

Genotype
MGI:3688727

• Allelic Composition: Psip1^{Gt(betageo)1Hgs}/Psip1^{Gt(betageo)1Hgs}
• Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * MF1)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, incomplete penetrance ( J:112975 )

• mice that survive to weaning usually survive more than 6 months

• most surviving mice are males

• Background Sensitivity: significant lethality on a mixed or outbred background but less severe than among congenics

behavior/neurological

absent gastric milk in neonates ( J:112975 )

• empty stomachs and intestinal tracts in mice that die perinatally - failure to nurse

limb grasping ( J:112975 )

• tendancy to clench toes and hold hind limbs against body when suspended by the tail

• behavior becomes more pronounced with age

decreased grip strength ( J:112975 )

• reduced

hunched posture ( J:112975 )

decreased vertical activity ( J:112975 )

• rearing on the hind limbs significantly reduced

decreased locomotor activity ( J:112975 )

• reduced activity in an open field test

immune system

spleen atrophy ( J:112975 )

• in mice that die perinatally

blepharitis ( J:112975 )

• persistent inflammation of the eyelids

adipose tissue

decreased total body fat amount ( J:112975 )

• very lean

abnormal abdominal fat pad morphology ( J:112975 )

• reduced intraabdominal fat

absent epididymal fat pad ( J:112975 )

• complete absence of epididymal fat pads

reproductive system

small testis ( J:112975 )

♂ • but no histological abnormalities of seminiferous tubules or interstitium

reduced male fertility ( J:112975 )

♂ • low fertility

vision/eye

vision/eye phenotype ( J:112975 )

N • lense epithelium is unexpectedly normal

blepharitis ( J:112975 )

• persistent inflammation of the eyelids

skeleton

abnormal axial skeleton morphology ( J:112975 )

abnormal cranium morphology ( J:112975 )

abnormal neurocranium morphology ( J:112975 )

• generally broader and shorter than normal

small interparietal bone ( J:112975 )

• reduced

small exoccipital bone ( J:112975 )

• reduced in size

small supraoccipital bone ( J:112975 )

• reduced in size

broad occipital bone ( J:112975 )

• broader and flatter than normal

flat occipital bone ( J:112975 )

• broader and flatter than normal

abnormal nasal bone morphology ( J:112975 )

• broader and shorter than normal

broad nasal bone ( J:112975 )

short nasal bone ( J:112975 )

domed cranium ( J:112975 )

• sometimes

short sternum ( J:112975 )

• shortened and positioned closer to the backbone

asymmetric rib joints ( J:112975 )

abnormal rib morphology ( J:112975 )

abnormal rib development ( J:112975 )

• an incomplete ectopic rib associated with cervical vertebra 7 and fused with the cartilage of the first thoracic rib

decreased rib number ( J:112975 )

abnormal spine curvature ( J:112975 )

• less curvature than normal

abnormal vertebrae morphology ( J:112975 )

abnormal cervical vertebrae morphology ( J:112975 )

abnormal cervical atlas morphology ( J:112975 )

• atlas is abnormally shaped

abnormal cervical axis morphology ( J:112975 )

• axis is abnormally shaped

decreased lumbar vertebrae number ( J:112975 )

• only five lumbar vertebrae

vertebral transformation ( J:112975 )

thoracic vertebral transformation ( J:112975 )

• prominent spinous process on T3 more typical of T2

cervical vertebral transformation ( J:112975 )

• C7 transformed toward T1

lumbar vertebral transformation ( J:112975 )

• L6 transformed to a sacral vertebra

craniofacial

abnormal cranium morphology ( J:112975 )

abnormal neurocranium morphology ( J:112975 )

• generally broader and shorter than normal

small interparietal bone ( J:112975 )

• reduced

small exoccipital bone ( J:112975 )

• reduced in size

small supraoccipital bone ( J:112975 )

• reduced in size

broad occipital bone ( J:112975 )

• broader and flatter than normal

flat occipital bone ( J:112975 )

• broader and flatter than normal

abnormal nasal bone morphology ( J:112975 )

• broader and shorter than normal

broad nasal bone ( J:112975 )

short nasal bone ( J:112975 )

domed cranium ( J:112975 )

• sometimes

short face ( J:112975 )

• shortened face

broad head ( J:112975 )

shortened head ( J:112975 )

• shortened face and jaws

endocrine/exocrine glands

small testis ( J:112975 )

♂ • but no histological abnormalities of seminiferous tubules or interstitium

hematopoietic system

spleen atrophy ( J:112975 )

• in mice that die perinatally

growth/size/body

abnormal nasal bone morphology ( J:112975 )

• broader and shorter than normal

broad nasal bone ( J:112975 )

short nasal bone ( J:112975 )

short face ( J:112975 )

• shortened face

broad head ( J:112975 )

shortened head ( J:112975 )

• shortened face and jaws

respiratory system

abnormal nasal bone morphology ( J:112975 )

• broader and shorter than normal

broad nasal bone ( J:112975 )

short nasal bone ( J:112975 )