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Phenotypes Associated with This Genotype
Genotype
MGI:3687542
Allelic
Composition		 Cd19tm1(cre)Cgn/Cd19+
Gt(ROSA)26Sortm4(Ikbkb)Rsky/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (12 available); any Cd19 mutation (61 available)
Gt(ROSA)26Sortm4(Ikbkb)Rsky mutation (2 available); any Gt(ROSA)26Sor mutation (1098 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
decreased B cell apoptosis ( J:113365 )
• 1-2 days after crosslinking with BCR, there are less apoptotic cells than in purified wild-type B cell cultures
increased cell proliferation ( J:113365 )
• 1-2 days after crosslinking with BCR, there are more cells is S phase than in wild-type B cell cultures

immune system
increased B cell number ( J:113365 )
• B cell numbers are increased in spleens (130 x 106) compared to wild-type (56 x 106)
abnormal splenic cell ratio ( J:113365 )
• B cell hyperplasia is observed, with a significantly expanded population of marginal zone B cells
abnormal B cell physiology ( J:113365 )
• cells on average have a longer lifespan than wild-type B cells
decreased B cell apoptosis ( J:113365 )
• 1-2 days after crosslinking with BCR, there are less apoptotic cells than in purified wild-type B cell cultures

hematopoietic system
increased B cell number ( J:113365 )
• B cell numbers are increased in spleens (130 x 106) compared to wild-type (56 x 106)
abnormal splenic cell ratio ( J:113365 )
• B cell hyperplasia is observed, with a significantly expanded population of marginal zone B cells
abnormal B cell physiology ( J:113365 )
• cells on average have a longer lifespan than wild-type B cells
decreased B cell apoptosis ( J:113365 )
• 1-2 days after crosslinking with BCR, there are less apoptotic cells than in purified wild-type B cell cultures

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory