Phenotypes Associated with This Genotype

Genotype
MGI:3665485

• Allelic Composition: Kit^W/Kit^W-v
• Genetic Background: (WB/ReJ x C57BL/6J-Kit^W-v/J)F1-Kit^W/Kit^W-v/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:113500 )

• significantly higher mortality is exhibited by mutants (88%) by day 21 after induction of anti-glomerular basement membrane glomerulonephritis than wild-type (25%)

cardiovascular system

abnormal response to cardiac infarction ( J:106065 )

• exhibit worse heart function and greater cardiac dilatation at 35 days after myocardial infarction than wild-type, showing decreased left ventricle end-systolic pressure and left ventricle thickness, increased left ventricle end-systolic volume, heart-to-body weight ratio, septal wall thickness, percentage of left ventricle infracted and collagen content, and significantly different stoke volume, and positive and negative dp/dt

• wild-type bone marrow transplanted into mutant mice rescues the adverse cardiac remodeling and impaired cardiac function after myocardial infarction and shows increased mobilization of angiogenic and natural killer cells

increased myocardial infarct size ( J:106065 )

• 35 days after myocardial infarction show increased percentage of left ventricle infracted

decreased vascular permeability ( J:84660 )

• do not display increased vascular permeability in the dura mater in response to acute restrain stress as is seen in wild-type controls

homeostasis/metabolism

abnormal response to cardiac infarction ( J:106065 )

• exhibit worse heart function and greater cardiac dilatation at 35 days after myocardial infarction than wild-type, showing decreased left ventricle end-systolic pressure and left ventricle thickness, increased left ventricle end-systolic volume, heart-to-body weight ratio, septal wall thickness, percentage of left ventricle infracted and collagen content, and significantly different stoke volume, and positive and negative dp/dt

• wild-type bone marrow transplanted into mutant mice rescues the adverse cardiac remodeling and impaired cardiac function after myocardial infarction and shows increased mobilization of angiogenic and natural killer cells

increased myocardial infarct size ( J:106065 )

• 35 days after myocardial infarction show increased percentage of left ventricle infracted

increased erythrocyte protoporphyrin level ( J:5985 )

• moderate but significant increase in protoporphrin levels in red blood cells compared to controls

abnormal interferon level ( J:131785 )

• treatment with Hrh4 antagonist (JNJ 10191584) during ovalbumin challenge results in decreased levels of IFN-gamma

abnormal interleukin level ( J:131785 )

• treatment with Hrh4 antagonist (JNJ 10191584) during ovalbumin challenge results in decreased levels of IL-4 (51%), IL-5 (35%), IL-6 (39%), and IL-17 (39%) in cultured peribronchiolar lymph nodes

increased urine protein level ( J:113500 )

• mice develop increased proteinuria compared to wild-type, 7 and 14 days after induction of anti-glomerular basement membrane (GBM) glomerulonephritis (GN)

abnormal response/metabolism to endogenous compounds ( J:123463 )

• mice exhibit reduced adenosine-induced airway responsiveness compared with wild-type mice

immune system

immune system phenotype ( J:125656 )

N • sensitized mice have a normal early phase reaction (initial phase of bronchoconstriction) after ovalbumin challenge

impaired neutrophil recruitment ( J:123463 )

• mice fail to exhibit adenosine-induced neutrophil recruitment unlike wild-type mice

abnormal interferon level ( J:131785 )

• treatment with Hrh4 antagonist (JNJ 10191584) during ovalbumin challenge results in decreased levels of IFN-gamma

abnormal interleukin level ( J:131785 )

• treatment with Hrh4 antagonist (JNJ 10191584) during ovalbumin challenge results in decreased levels of IL-4 (51%), IL-5 (35%), IL-6 (39%), and IL-17 (39%) in cultured peribronchiolar lymph nodes

decreased inflammatory response ( J:131785 )

• treatment with Hrh4 antagonist (JNJ 10191584) during ovalbumin challenge results in decreased total bronchoalveolar lavage cell numbers (54%) and eosinophils (75%)

kidney inflammation ( J:113500 )

• more T cells and macrophages infiltrate kidneys compared to control mice; increased numbers of CD4+ T cells and macrophages are found in glomeruli compared to controls on day 14 after anti-GBM GN

renal/urinary system

increased urine protein level ( J:113500 )

• mice develop increased proteinuria compared to wild-type, 7 and 14 days after induction of anti-glomerular basement membrane (GBM) glomerulonephritis (GN)

kidney inflammation ( J:113500 )

• more T cells and macrophages infiltrate kidneys compared to control mice; increased numbers of CD4+ T cells and macrophages are found in glomeruli compared to controls on day 14 after anti-GBM GN

abnormal renal glomerulus morphology ( J:113500 )

• in mice there is accumulation of PAS stain-positive material as well as crescent formation in glomeruli, compared to wild-type

glomerular crescent ( J:113500 )

• crescent formation in glomeruli

hematopoietic system

increased erythrocyte protoporphyrin level ( J:5985 )

• moderate but significant increase in protoporphrin levels in red blood cells compared to controls

impaired neutrophil recruitment ( J:123463 )

• mice fail to exhibit adenosine-induced neutrophil recruitment unlike wild-type mice

respiratory system

decreased airway responsiveness ( J:123463 )

• mice exhibit reduced adenosine-induced airway responsiveness and neutrophil recruitment compared with wild-type mice