Phenotypes Associated with This Genotype

Genotype
MGI:3663264

• Allelic Composition: T/T⁺
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

limbs/digits/tail

decreased ventral ectodermal ridge size ( J:15081 )

• the size of the ventral ectodermal ridge of the tail (VER) is reduced to 74% of normal size

decreased caudal vertebrae number ( J:15081 )

• caudal vertebrae numbers range from 10 to 24, with an average of 21

short tail ( J:15081 , J:13018 )

• tail is reduced by about 1/3 in most mutants (J:15081)

• seen by E11 (J:13018)

embryo

abnormal neural tube morphology ( J:13018 )

• neural tube is abnormal/misshapen in the ventral part and in cases in which the notochord is abnormal

abnormal notochord morphology ( J:15081 , J:13018 )

• contain a notochord, however it can be retained in the roof of the gut or cloaca for varying distances and for a limited period, it may be slow to separate from the overlying neural plate or neural tube, or it may secondarily become incorporated completely into the neural tube or the tail-gut (J:15081)

• the notocord has a central lumen in places (J:15081)

• commonly see branching of the notochord proper; at E10-12.5, branches occur mainly in the region of the cloaca and the proximal parts of the tail (J:15081)

decreased ventral ectodermal ridge size ( J:15081 )

• the size of the ventral ectodermal ridge of the tail (VER) is reduced to 74% of normal size

skeleton

decreased caudal vertebrae number ( J:15081 )

• caudal vertebrae numbers range from 10 to 24, with an average of 21

decreased presacral vertebrae number ( J:15081 )

nervous system

abnormal neural tube morphology ( J:13018 )

• neural tube is abnormal/misshapen in the ventral part and in cases in which the notochord is abnormal