Phenotypes Associated with This Genotype

Genotype
MGI:3628582

• Allelic Composition: Dclk1^tm1Caw/Dclk1^tm1Caw; Dcx^tm1Caw/Y
• Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:105301 )

♂ • more than 75% of double knockouts die within 2 days of birth

nervous system

abnormal brain morphology ( J:105301 )

♂ • double knockouts exhibit disruption of most or all major axon tracts in the brain; brains of double knockouts display severely disorganized white-matter tracts

abnormal cerebellar foliation ( J:105301 )

♂ • cerebellum of mutants has defective foliation; folia are severely hypoplastic, particularly on the ventral surface of the cerebellum

abnormal corpus callosum morphology ( J:105301 )

♂ • there are no fibers crossing the midline of the corpus callosum; most axons end before reaching the midline and do not cross to the other side

♂ • axons appear as multiple single axons with random orientation and without clear fasciculation rather than bundles

decreased corpus callosum size ( J:105301 )

♂ • in mutants, corpus callosum is present at rostral levels but does not extend as far caudally as in wild-type mice; anterior portion is greatly reduced in thickness

abnormal hippocampal commissure morphology ( J:105301 )

♂ • hippocampal commissures appear lumpy and disorganized

abnormal anterior commissure morphology ( J:105301 )

♂ • aberrant anterior commissure bundles are observed

abnormal brain internal capsule morphology ( J:105301 )

♂ • in some animals, internal capsule has abnormal morphology

absent brain internal capsule ( J:105301 )

♂ • there is absence of an internal capsule in the striatum

abnormal brainstem morphology ( J:105301 )

♂ • disruption of many brainstem nuclei is observed

abnormal striatum morphology ( J:105301 )

♂ • there is absence of pencil fibers in the striatum

abnormal thalamus morphology ( J:105301 )

♂ • disruption of many thalamic nuclei is observed

abnormal cerebral cortex morphology ( J:105301 )

♂ • stratum pyramidale layer in pyramidal cell fields, CA3,CA2and CA1 is disorganized with multiple cell layers separated by irregular streams of white matter

disorganized cerebral cortex lamination ( J:105301 )

♂ • at P0, there is disruption of lamination of the cerebral cortex in the cingulate gyrus in double knockouts

thin cerebral cortex ( J:105301 )

♂ • brains of double knockouts at P0 display a thin cerebral cortex

abnormal temporal lobe morphology ( J:105301 )

♂

abnormal entorhinal cortex morphology ( J:105301 )

♂ • no axons leave the region of the entorhinal cortex

abnormal hippocampus morphology ( J:105301 )

♂ • subcortical white matter appears lumpy and disorganized

abnormal dentate gyrus morphology ( J:105301 )

♂ • cells appear less tightly packed

abnormal hippocampus layer morphology ( J:105301 )

♂ • there is markedly abnormal cell layering in the hippocampus

small cerebellum ( J:105301 )

♂ • the cerebellum is small in double knockouts