Mouse Genome Informatics

involves: 129S4/SvJae * BALB/c * C57BL/6 * FVB/N
phenotype observed in females
phenotype observed in males
N normal phenotype
• most die at about 10 weeks of age without obvious correlation between physical deterioration and time of death

• appear healthy for the first few weeks of age but develop abnormal behavior, such as nervousness, at 5 weeks of age
• exhibit body trembling at 5 weeks of age
• at late stages of disease, mutants tremble when handled
• seen at late stages of disease

nervous system
• neurons in the CA2 region are 15-25% smaller than in controls at 8 weeks of age
• cell bodies and nuclei or neurons in sections of hippocampus, cerebral cortex, and cerebellum are smaller in size and more densely packed

• most exhibit signs of physical deterioration by 8 weeks of age and often begin to lose weight at late stages of disease
• 6 of 18 become overweight and obese at 40-60 days of age

respiratory system
• occasionally show heavy breathing at 5 weeks of age

Mouse Models of Human Disease
Rett Syndrome; RTT 312750 J:67909