Mouse Genome Informatics
cn
    Mecp2tm1Jae/Y
Tg(Nes-cre)1Atp/0

involves: 129S4/SvJae * BALB/c * C57BL/6 * FVB/N
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• most die at about 10 weeks of age without obvious correlation between physical deterioration and time of death (J:67909)

behavior/neurological
• appear healthy for the first few weeks of age but develop abnormal behavior, such as nervousness, at 5 weeks of age (J:67909)
• exhibit body trembling at 5 weeks of age (J:67909)
• at late stages of disease, mutants tremble when handled (J:67909)
• seen at late stages of disease (J:67909)

nervous system
• neurons in the CA2 region are 15-25% smaller than in controls at 8 weeks of age (J:67909)
• cell bodies and nuclei or neurons in sections of hippocampus, cerebral cortex, and cerebellum are smaller in size and more densely packed (J:67909)

growth/size
• most exhibit signs of physical deterioration by 8 weeks of age and often begin to lose weight at late stages of disease (J:67909)
• 6 of 18 become overweight and obese at 40-60 days of age (J:67909)

respiratory system
• occasionally show heavy breathing at 5 weeks of age (J:67909)

Mouse Models of Human Disease
OMIM IDRef(s)
Rett Syndrome; RTT 312750 J:67909