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Phenotypes Associated with This Genotype
Genotype
MGI:3623407
Allelic
Composition		 Tgfbr2tm1Karl/Tgfbr2tm1Karl
Tg(Tie1-cre)9Ref/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tgfbr2tm1Karl mutation (1 available); any Tgfbr2 mutation (40 available)
Tg(Tie1-cre)9Ref mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, complete penetrance ( J:98373 )
• embryonic lethality at mid gestation

embryo
abnormal vitelline vasculature morphology ( J:98373 )
• develop similar yolk sac defects as Tgfbr2 null mice

cardiovascular system
abnormal vitelline vasculature morphology ( J:98373 )
• develop similar yolk sac defects as Tgfbr2 null mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory