Phenotypes Associated with This Genotype

Genotype
MGI:3623313

• Allelic Composition: Egfr^wa2/Egfr^Wa5
• Genetic Background: involves: BALB/cAnN * C3H/HeN * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Phenotypes of Egfr^wa2/Egfr^Wa5 and Tgfa^tm1Unc/Tgfa^tm1Unc Egfr^Wa5/⁺ mice

mortality/aging

perinatal lethality, incomplete penetrance ( J:92308 )

• born at about half the expected rate

postnatal lethality, incomplete penetrance ( J:92308 )

• heavy death rate over the first 3 weeks of life

growth/size/body

mandible hypoplasia ( J:92308 )

• underdeveloped lower jaw

asymmetric snout ( J:92308 )

• narrow, asymmetric snout

long snout ( J:92308 )

• elongated snout

narrow snout ( J:92308 )

• narrow, asymmetric snout

decreased body weight ( J:92308 )

• body weight ranges from 30-50% of controls in mutants that survive for 3 months after birth

postnatal growth retardation ( J:92308 )

• 25% reduction in body size in mice surviving to 6 weeks of age

craniofacial

mandible hypoplasia ( J:92308 )

• underdeveloped lower jaw

asymmetric snout ( J:92308 )

• narrow, asymmetric snout

long snout ( J:92308 )

• elongated snout

narrow snout ( J:92308 )

• narrow, asymmetric snout

reproductive system

delayed vaginal opening ( J:92308 )

♀ • vaginal opening delayed until around 11 months of age

abnormal fertility/fecundity ( J:92308 )

• no offspring produced by either sex by 3 months of age

skeleton

mandible hypoplasia ( J:92308 )

• underdeveloped lower jaw

vision/eye

abnormal eye morphology ( J:92308 )

• eye defects

integument

alopecia ( J:92308 )

• complete hair loss occurs around 8 weeks of age with resumption of hair growth sometime thereafter

loss of vibrissae ( J:92308 )