Phenotypes Associated with This Genotype

Genotype
MGI:3621359

• Allelic Composition: S1pr3^tm1Rlp/S1pr3^tm1Rlp; S1pr2^tm1Rlp/S1pr2^tm1Rlp
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Hemorrhage in S1pr2^tm1Rlp/S1pr2^tm1Rlp S1pr3^tm1Rlp/S1pr3^tm1Rlp embryos

mortality/aging

lethality throughout fetal growth and development, incomplete penetrance ( J:106055 )

• partial lethality after E13.5

• lethality is increased when crosses consist of double homozygous parents

prenatal lethality, incomplete penetrance ( J:121165 )

• ~50% of double homozygotes die in utero with angiogenic defects

cardiovascular system

abnormal vascular endothelial cell morphology ( J:106055 )

• abnormally thin endothelial cells are seen in many of the microvessels; however the aorta is normally covered by smooth muscle cells

hemorrhage ( J:106055 )

• many of the viable double homozygotes display hemorrhages beginning at E13.5

reproductive system

increased miscarriage rate ( J:106055 )

♀ • intercrosses of double homozygous parents result in most litters being spontaneously aborted

reduced fertility ( J:106055 )

• intercrosses of double homozygous parents result in most litters being spontaneously aborted with only a few small litters delivered

nervous system

cochlear ganglion degeneration ( J:121165 )

• at 6 months, double homozygotes display a striking bilateral loss of spiral ganglion neurons, not observed in single Edg3^tm1Rlp homozygotes

behavior/neurological

head tilt ( J:121165 )

• at 3 months, ~20% of surviving double homozygotes develop a pronounced head tilt

homeostasis/metabolism

skin edema ( J:106055 )

integument

skin edema ( J:106055 )