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Phenotypes Associated with This Genotype
Genotype
MGI:3620975
Allelic
Composition
Lystbg-grey/Lystbg-grey
Genetic
Background
C57BL/6-Lystbg-grey
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lystbg-grey mutation (0 available); any Lyst mutation (117 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Morphologic investigation of Lystbg-grey/Lystbg-grey and +/+ wild-type mice.

pigmentation
• by the end of hair follicle morphogenesis, the coat of mutants is grey due to intermingling or nonpigmented or scarcely pigmented hair fibers with black hairs
• fusions of melanosomes of various maturation stages are found
• melanocytes in the iris contain melanosomes of different stages of maturation side by side
• mutant melanosomes are larger and irregularly shaped; melanocytes contain melanosomes of different stages of maturation
• melanocytes in the choroid of the eye are irregular in shape and larger than controls
• melanosomes are larger and irregularly shaped compared with control mice
• compared with wild-type, hair folicle and choroid melanocytes are larger and irregulary shaped
• melanosomes of hair follicles are larger and irregular in shape compared to wild-type
• melanosomes of hair follicles are larger and irregular in shape compared to wild-type

vision/eye
• fusions of melanosomes of various maturation stages are found
• melanocytes in the iris contain melanosomes of different stages of maturation side by side
• mutant melanosomes are larger and irregularly shaped; melanocytes contain melanosomes of different stages of maturation

hematopoietic system
• in mutants, the secretory granules in dermal mast cells are larger and of different sizes, while in wild-type they are of smaller, uniform size

immune system
• in mutants, the secretory granules in dermal mast cells are larger and of different sizes, while in wild-type they are of smaller, uniform size

integument
• melanosomes are larger and irregularly shaped compared with control mice
• melanosomes of hair follicles are larger and irregular in shape compared to wild-type
• melanosomes of hair follicles are larger and irregular in shape compared to wild-type
• by the end of hair follicle morphogenesis, the coat of mutants is grey due to intermingling or nonpigmented or scarcely pigmented hair fibers with black hairs
• in mutants, the secretory granules in dermal mast cells are larger and of different sizes, while in wild-type they are of smaller, uniform size

Mouse Models of Human Disease
OMIM ID Ref(s)
Chediak-Higashi Syndrome; CHS 214500 J:106442


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory