Mouse Genome Informatics
hm
    Lystbg-grey/Lystbg-grey
C57BL/6-Lystbg-grey
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       

Morphologic investigation of Lystbg-grey/Lystbg-grey and +/+ wild-type mice.

pigmentation
• by the end of hair follicle morphogenesis, the coat of mutants is grey due to intermingling or nonpigmented or scarcely pigmented hair fibers with black hairs
• mutant melanosomes are larger and irregularly shaped; melanocytes contain melanosomes of different stages of maturation
• fusions of melanosomes of various maturation stages are found
• altered melanosomes are observed
• melanocytes in the iris contain melanosomes of different stages of maturation side by side
• melanocytes in the choroid of the eye are irregular in shape and larger than controls
• melanosomes are larger and irregularly shaped compared with control mice
• compared with wild-type, hair folicle and choroid melanocytes are larger and irregulary shaped
• melanosomes of hair follicles are larger and irregular in shape compared to wild-type
• melanosomes of hair follicles are larger and irregular in shape compared to wild-type

vision/eye
• mutant melanosomes are larger and irregularly shaped; melanocytes contain melanosomes of different stages of maturation
• fusions of melanosomes of various maturation stages are found
• melanocytes in the iris contain melanosomes of different stages of maturation side by side
• altered melanosomes are observed

hematopoietic system
• in mutants, the secretory granules in dermal mast cells are larger and of different sizes, while in wild-type they are of smaller, uniform size

immune system
• in mutants, the secretory granules in dermal mast cells are larger and of different sizes, while in wild-type they are of smaller, uniform size

integument
• melanosomes are larger and irregularly shaped compared with control mice
• melanosomes of hair follicles are larger and irregular in shape compared to wild-type
• melanosomes of hair follicles are larger and irregular in shape compared to wild-type
• by the end of hair follicle morphogenesis, the coat of mutants is grey due to intermingling or nonpigmented or scarcely pigmented hair fibers with black hairs
• in mutants, the secretory granules in dermal mast cells are larger and of different sizes, while in wild-type they are of smaller, uniform size

Mouse Models of Human Disease
OMIM IDRef(s)
Chediak-Higashi Syndrome; CHS 214500 J:106442