About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3620761
Allelic
Composition
Rr149356tm1Che/Rr149356tm1Che
Tcrdtm1Mom/Tcrdtm1Mom
Trp53tm1Tyj/Trp53tm1Tyj
Genetic
Background
involves: 129P2/OlaHsd * 129S2/SvPas * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rr149356tm1Che mutation (0 available); any Rr149356 mutation (0 available)
Tcrdtm1Mom mutation (13 available); any Tcrd mutation (16 available)
Trp53tm1Tyj mutation (12 available); any Trp53 mutation (249 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• most thymocytes are double negative at 4 weeks of age but quickly progress to double positive and then CD8 single positive lymphomas
• mean survival around 14 weeks
• most thymocytes are double negative at 4 weeks of age but quickly progress to double positive and then CD8 single positive lymphomas

neoplasm
• most thymocytes are double negative at 4 weeks of age but quickly progress to double positive and then CD8 single positive lymphomas
• mean survival around 14 weeks

hematopoietic system
• most thymocytes are double negative at 4 weeks of age but quickly progress to double positive and then CD8 single positive lymphomas
• mean survival around 14 weeks
• most thymocytes are double negative at 4 weeks of age but quickly progress to double positive and then CD8 single positive lymphomas

endocrine/exocrine glands
• most thymocytes are double negative at 4 weeks of age but quickly progress to double positive and then CD8 single positive lymphomas
• mean survival around 14 weeks


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/25/2025
MGI 6.24
The Jackson Laboratory