Phenotypes Associated with This Genotype

Genotype
MGI:3620761

• Allelic Composition: Rr149356^tm1Che/Rr149356^tm1Che; Tcrd^tm1Mom/Tcrd^tm1Mom; Trp53^tm1Tyj/Trp53^tm1Tyj
• Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased T cell derived lymphoma incidence ( J:106246 )

• most thymocytes are double negative at 4 weeks of age but quickly progress to double positive and then CD8 single positive lymphomas

• mean survival around 14 weeks

abnormal double-negative T cell morphology ( J:106246 )

• most thymocytes are double negative at 4 weeks of age but quickly progress to double positive and then CD8 single positive lymphomas

neoplasm

increased T cell derived lymphoma incidence ( J:106246 )

• most thymocytes are double negative at 4 weeks of age but quickly progress to double positive and then CD8 single positive lymphomas

• mean survival around 14 weeks

hematopoietic system

increased T cell derived lymphoma incidence ( J:106246 )

• most thymocytes are double negative at 4 weeks of age but quickly progress to double positive and then CD8 single positive lymphomas

• mean survival around 14 weeks

abnormal double-negative T cell morphology ( J:106246 )

• most thymocytes are double negative at 4 weeks of age but quickly progress to double positive and then CD8 single positive lymphomas

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:106246 )

• most thymocytes are double negative at 4 weeks of age but quickly progress to double positive and then CD8 single positive lymphomas

• mean survival around 14 weeks