Phenotypes Associated with This Genotype

Genotype
MGI:3620760

• Allelic Composition: Rr149356^tm1Che/Rr149356^tm1Che; Trp53^tm1Tyj/Trp53^tm1Tyj
• Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased T cell derived lymphoma incidence ( J:106246 )

• 2/3 of mice develop thymic lymphomas

• single positive Cd8 cells are immature and abnormal, make up 60% of thymocytes by 8 weeks

• large terminal lymphomas present by 11-17 weeks of age

• mean survival of 14 weeks

abnormal double-negative T cell morphology ( J:106246 )

• 24% of double negative thymocytes are apoptotic

abnormal double-positive T cell morphology ( J:106246 )

• 36% of double positive thymocytes are apoptotic

• double positive cells start losing CD4 expression around 7 weeks to become CD8 single positive

neoplasm

increased T cell derived lymphoma incidence ( J:106246 )

• 2/3 of mice develop thymic lymphomas

• single positive Cd8 cells are immature and abnormal, make up 60% of thymocytes by 8 weeks

• large terminal lymphomas present by 11-17 weeks of age

• mean survival of 14 weeks

decreased metastatic potential ( J:106246 )

• inefficient metastasis

hematopoietic system

increased T cell derived lymphoma incidence ( J:106246 )

• 2/3 of mice develop thymic lymphomas

• single positive Cd8 cells are immature and abnormal, make up 60% of thymocytes by 8 weeks

• large terminal lymphomas present by 11-17 weeks of age

• mean survival of 14 weeks

abnormal double-negative T cell morphology ( J:106246 )

• 24% of double negative thymocytes are apoptotic

abnormal double-positive T cell morphology ( J:106246 )

• 36% of double positive thymocytes are apoptotic

• double positive cells start losing CD4 expression around 7 weeks to become CD8 single positive

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:106246 )

• 2/3 of mice develop thymic lymphomas

• single positive Cd8 cells are immature and abnormal, make up 60% of thymocytes by 8 weeks

• large terminal lymphomas present by 11-17 weeks of age

• mean survival of 14 weeks