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Phenotypes Associated with This Genotype
Genotype
MGI:3620636
Allelic
Composition		 Keap1tm1Mym/Keap1tm2Mym
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Keap1tm1Mym mutation (1 available); any Keap1 mutation (34 available)
Keap1tm2Mym mutation (0 available); any Keap1 mutation (34 available)
Speer6-ps1Tg(Alb-cre)21Mgn mutation (6 available); any Speer6-ps1 mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased susceptibility to xenobiotic induced morbidity/mortality ( J:103791 )
• unlike most wild-type mice, mutant mice survive following intraperitoneal administration of 600-mg or 700-mg acetaminophen/kg body weight

homeostasis/metabolism
decreased susceptibility to xenobiotic induced morbidity/mortality ( J:103791 )
• unlike most wild-type mice, mutant mice survive following intraperitoneal administration of 600-mg or 700-mg acetaminophen/kg body weight
decreased physiological sensitivity to xenobiotic ( J:103791 )
• much milder hepatic injury in livers of mutant mice following acetaminophen exposure

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory