Phenotypes Associated with This Genotype

Genotype
MGI:3619927

• Allelic Composition: Pten^tm2Mak/Pten^tm2Mak; Tg(Ckmm-cre)5Khn/0
• Genetic Background: involves: 129P2/OlaHsd * FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal heart morphology ( J:79151 )

• exhibit an increase in the anterior wall thickness, however see no evidence of wall thinning or tissue fibrosis and heart rate is normal

increased myocardial fiber size ( J:79151 )

• increase in both the length and width of cardiomyocytes

enlarged heart ( J:79151 )

• increased in heart size is detectable in newborns

cardiac hypertrophy ( J:79151 )

• seen at 10 weeks and 12 months of age, however do not observe cardiac decompensation or dilated cardiomyopathy

abnormal heart left ventricle morphology ( J:79151 )

• exhibit an increase in the left ventricle mass

decreased cardiac muscle contractility ( J:79151 )

• decrease in fractional shortening, velocity of circumferential fiber shortening, peak aortic outflow velocity, dP/dT-max and dP/dT-min, indicating impaired contractile heart function

• individual cardiomyocytes display a reduction in contractility as shown by a reduction in percent cell shortening and positive and negative dL/dTs

muscle

increased myocardial fiber size ( J:79151 )

• increase in both the length and width of cardiomyocytes

decreased cardiac muscle contractility ( J:79151 )

• decrease in fractional shortening, velocity of circumferential fiber shortening, peak aortic outflow velocity, dP/dT-max and dP/dT-min, indicating impaired contractile heart function

• individual cardiomyocytes display a reduction in contractility as shown by a reduction in percent cell shortening and positive and negative dL/dTs

growth/size/body

enlarged heart ( J:79151 )

• increased in heart size is detectable in newborns

cardiac hypertrophy ( J:79151 )

• seen at 10 weeks and 12 months of age, however do not observe cardiac decompensation or dilated cardiomyopathy