Phenotypes for Dclk1 Dcx MGI:3618309 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Dclk1^tm1.1Jgg/Dclk1^tm1.1Jgg Dcx^tm1Caw/Dcx^tm1Caw
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dclk1^tm1.1Jgg mutation (0 available); any Dclk1 mutation (53 available)
Dcx^tm1Caw mutation (0 available); any Dcx mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:105300 )

• pups die before weaning, usually soon after birth

nervous system

abnormal brain commissure morphology ( J:105300 )

absent corpus callosum ( J:105300 )

• corpus callosum is absent

absent hippocampal commissure ( J:105300 )

absent anterior commissure ( J:105300 )

abnormal stratification in cerebral cortex ( J:105300 )

• there is no apparent laminar structure to the cortex

abnormal neuron morphology ( J:105300 )

• cortical neuron distribution is altered, showing a broader pattern of distribution

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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