Phenotypes Associated with This Genotype

Genotype
MGI:3615666

• Allelic Composition: Hivep2^tm1Sis/Hivep2^tm1Sis; Tg(DO11.10)10Dlo/?
• Genetic Background: involves: BALB/cA * C3H * C57BL/6NCrlj * CBA/JNCrlj

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal positive T cell selection ( J:96024 )

• impaired positive selection

decreased single-positive T cell number ( J:72249 )

• marked reduction in CD4+ single positive t cells after ovalbumin administration relative to controls

• both CD4+ and CD8+ single positive splenocytes reduced after ovalbumin administration

abnormal T-helper 2 cell morphology ( J:96024 )

• enhanced generation of TH2 cells

• TH1 differentiation unaffected

hematopoietic system

abnormal positive T cell selection ( J:96024 )

• impaired positive selection

decreased single-positive T cell number ( J:72249 )

• marked reduction in CD4+ single positive t cells after ovalbumin administration relative to controls

• both CD4+ and CD8+ single positive splenocytes reduced after ovalbumin administration

abnormal T-helper 2 cell morphology ( J:96024 )

• enhanced generation of TH2 cells

• TH1 differentiation unaffected