Phenotypes Associated with This Genotype

Genotype
MGI:3609196

• Allelic Composition: Ret^tm2(RET)Vpa/Ret^tm2(RET)Vpa
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, incomplete penetrance ( J:71588 )

• less than 5% of homozygotes survive to 2 -3 months of age

growth/size/body

kidney cyst ( J:71588 )

postnatal growth retardation ( J:71588 )

• surviving homozygotes display severe growth retardation

nervous system

absent enteric neural crest cell ( J:71588 )

• no enteric neural crest cells are seen in the terminal 3/4 of the colon at any time from E11.5 to E13.5

abnormal enteric ganglia morphology ( J:71588 )

• enteric ganglia are severely reduced or absent in the terminal 3/4 of the colon and reduced but present in the remaining 1/4 of the colon

renal/urinary system

abnormal kidney morphology ( J:71588 )

• dysplastic

kidney cyst ( J:71588 )

renal hypoplasia ( J:71588 )

• kidneys are 1/3 to 1/4 the volume of wild-type kidneys with fewer nephrons

impaired branching involved in ureteric bud morphogenesis ( J:71588 )

• onset of ureteric bud development is normal (at E10.5 and E12.5) but at E13.5 the number of ureteric bud branches is reduced and this reduction becomes more severe with age

embryo

abnormal enteric neural crest cell migration ( J:71588 )

• failure of enteric neural crest cells to colonize the colon during embryogenesis

absent enteric neural crest cell ( J:71588 )

• no enteric neural crest cells are seen in the terminal 3/4 of the colon at any time from E11.5 to E13.5

cellular

abnormal enteric neural crest cell migration ( J:71588 )

• failure of enteric neural crest cells to colonize the colon during embryogenesis