Phenotypes Associated with This Genotype

Genotype
MGI:3609116

• Allelic Composition: Itgb8^tm1Lfr/Itgb8^tm2Lfr; Tg(Nes-cre)1Kln/0
• Genetic Background: involves: 129/Sv * 129X1/SvJ * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal blood vessel morphology ( J:102190 )

• blood vessels in the brain do not run parallel to the astroglia

abnormal vascular endothelial cell morphology ( J:102190 )

• vessels in the brain develop large irregular endothelial cell clusters

intracranial hemorrhage ( J:102190 )

• at P0 hemorrhages are seen in the dorsal cortex, thalamus, and in the ganglionic eminence near the deep mesencephalic nucleus; however hemorrhages are not seen in adult mutants and no cortical lamination defects are seen in adults

• hemorrhaging is less severe than in mice homozygous for Itgb8^tm1Lfr

nervous system

intracranial hemorrhage ( J:102190 )

• at P0 hemorrhages are seen in the dorsal cortex, thalamus, and in the ganglionic eminence near the deep mesencephalic nucleus; however hemorrhages are not seen in adult mutants and no cortical lamination defects are seen in adults

• hemorrhaging is less severe than in mice homozygous for Itgb8^tm1Lfr

abnormal astrocyte morphology ( J:102190 )

• at E14.5 radial glia near the ganglionic eminence (where hemorrhaging could be seen) are disorganized but those in the developing cortex (where hemorrhages are not yet present) appear normal

• at P0 astroglia appear disorganized and lack the normal parallel organization

• blood vessels in the brain do not run parallel to the astoglia

cellular

abnormal astrocyte morphology ( J:102190 )

• at E14.5 radial glia near the ganglionic eminence (where hemorrhaging could be seen) are disorganized but those in the developing cortex (where hemorrhages are not yet present) appear normal

• at P0 astroglia appear disorganized and lack the normal parallel organization

• blood vessels in the brain do not run parallel to the astoglia