Phenotypes Associated with This Genotype

Genotype
MGI:3606678

• Allelic Composition: Uchl1^tm1Dgen/Uchl1^tm1Dgen
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

increased coping response ( J:101679 )

• exhibit a significant decrease in time immobile during tail suspension testing, which may be associated with a decreased depression-like state

impaired coordination ( J:101679 , J:207278 )

• exhibit a significant decrease in motor performance on the rotarod test, falling from the rotarod at significantly slower speeds than wildtype (J:101679)

• mice start to show motor deficits on the rotating beam by 2.5 months of age (J:207278)

decreased grip strength ( J:207278 )

• muscle weakness is apparent at 4.5 months of age but not at 2.5 months of age

increased thermal nociceptive threshold ( J:101679 )

• exhibit a significant increase in thermal response latency during hot plate testing

growth/size/body

weight loss ( J:207278 )

• mice start to show a slight weight loss by 2.5 months of age