Phenotypes Associated with This Genotype

Genotype
MGI:3590221

• Allelic Composition: Caml^tm1Rjb/Caml^tm2Rjb; Tg(Lck-cre)1Cwi/0; Tg(TcraTcrb)1100Mjb/0
• Genetic Background: involves: 129 * C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

decreased thymocyte number ( J:100536 )

• reduced numbers of total thymocytes

abnormal negative T cell selection ( J:100536 )

• in an in vitro assay, mutant thymocytes underwent OCA peptide 257-264 dependent cell death more readily than control, indicating enhanced negative selection

abnormal positive T cell selection ( J:100536 )

• lower proportions of double-positive and single-positive cells, and reduced CD8 SP cell in the peripheral T cell population, both indicating impaired positive selection

immune system

decreased thymocyte number ( J:100536 )

• reduced numbers of total thymocytes

abnormal negative T cell selection ( J:100536 )

• in an in vitro assay, mutant thymocytes underwent OCA peptide 257-264 dependent cell death more readily than control, indicating enhanced negative selection

abnormal positive T cell selection ( J:100536 )

• lower proportions of double-positive and single-positive cells, and reduced CD8 SP cell in the peripheral T cell population, both indicating impaired positive selection

endocrine/exocrine glands

decreased thymocyte number ( J:100536 )

• reduced numbers of total thymocytes