Phenotypes Associated with This Genotype

Genotype
MGI:3584506

• Allelic Composition: Foxp2^tm1Bux/Foxp2^tm1Bux
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Histological analysis of brains of Foxp2^tm1Bux and wild type mice

mortality/aging

postnatal lethality, complete penetrance ( J:99864 )

• homozygotes typically die by 21 days of age; however, maternal care of homozygotes and feeding appear normal

behavior/neurological

abnormal reflex ( J:99864 )

• mean righting during a fall is reduced

impaired righting response ( J:99864 )

• righting response is delayed

decreased locomotor activity ( J:99864 )

• decreased spontaneous activity

positive geotaxis ( J:99864 )

decreased vocalization ( J:99864 )

• at 6 days of age the incidence of vocalization over time is reduced and at 10 days of age a profound decrease in ultrasonic vocalizations and the incidence of clicks is observed; however the duration, peak frequency, and bandwidth of the vocalizations are normal

nervous system

abnormal radial glial cell morphology ( J:99864 )

• gaps are seen in the glial network while in some areas glial fibers appear clumped

abnormal cerebellum external granule cell layer morphology ( J:99864 )

• a 3 - 4 cell thick external granule cell layer is seen at 15 - 17 days of age; however increased apoptosis is not seen in this layer

abnormal cerebellar Purkinje cell layer ( J:99864 )

• Purkinje cells frequently fail to align in a continuous row, often forming a layer that is several cells thick with ectopic ells in the granule cell layer

abnormal Purkinje cell dendrite morphology ( J:99864 )

• the dendritic arbors are less elaborate and often aligned at oblique angles

thin cerebellar molecular layer ( J:99864 )

• the molecular layer is about half the thickness of wild-type

growth/size/body

delayed ear emergence ( J:99864 )

postnatal growth retardation ( J:99864 )

hearing/vestibular/ear

delayed ear emergence ( J:99864 )

vision/eye

delayed eyelid opening ( J:99864 )

craniofacial

delayed ear emergence ( J:99864 )

cellular

abnormal radial glial cell morphology ( J:99864 )

• gaps are seen in the glial network while in some areas glial fibers appear clumped