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Phenotypes Associated with This Genotype
Genotype
MGI:3584126
Allelic
Composition		 Mcm3aptm1Imku/Mcm3aptm1Imku
Cd19tm1(cre)Cgn/Cd19+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (12 available); any Cd19 mutation (57 available)
Mcm3aptm1Imku mutation (0 available); any Mcm3ap mutation (78 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased B cell proliferation ( J:88276 )
• B cell proliferation is slightly impaired in response to CD40/CD50 stimulation but not in response to LPS stimulation
abnormal memory B cell number ( J:88276 )
• decrease in the memory B cell population
decreased germinal center B cell number ( J:88276 )
• decrease in the germinal center B cell population
abnormal spleen germinal center morphology ( J:88276 )
• germinal center formation is delayed in response to T cell dependent antigen stimulation
abnormal germinal center B cell physiology ( J:88276 )
• after antigen stimulation increased apoptosis is seen in germinal center B cells
decreased IgG level ( J:88276 )
• antibody response (IgG1) to NP25-BSA is markedly reduced with the decrease occurring because of a decrease in the germinal center B cell and memory B cell populations

hematopoietic system
decreased B cell proliferation ( J:88276 )
• B cell proliferation is slightly impaired in response to CD40/CD50 stimulation but not in response to LPS stimulation
abnormal memory B cell number ( J:88276 )
• decrease in the memory B cell population
decreased germinal center B cell number ( J:88276 )
• decrease in the germinal center B cell population
abnormal spleen germinal center morphology ( J:88276 )
• germinal center formation is delayed in response to T cell dependent antigen stimulation
abnormal germinal center B cell physiology ( J:88276 )
• after antigen stimulation increased apoptosis is seen in germinal center B cells
decreased IgG level ( J:88276 )
• antibody response (IgG1) to NP25-BSA is markedly reduced with the decrease occurring because of a decrease in the germinal center B cell and memory B cell populations

cellular
decreased B cell proliferation ( J:88276 )
• B cell proliferation is slightly impaired in response to CD40/CD50 stimulation but not in response to LPS stimulation

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory