Mcm3ap^tm1Imku
Targeted Allele Detail

Summary

• Symbol: Mcm3ap^tm1Imku
• Name: minichromosome maintenance complex component 3 associated protein; targeted mutation 1, Nobuo Sakaguchi
• MGI ID: MGI:3583894
• Synonyms: ganp flox
• Gene: Mcm3ap Location: Chr10:76304761-76351691 bp, + strand Genetic Position: Chr10, 38.88 cM
• Alliance: Mcm3ap^tm1Imku page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:88276
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to insert a neomycin resistance gene downstream of exon 2. LoxP sites were inserted to flank exon 2 and the neo cassette. (J:88276)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mcm3ap Mutation: 77 strains or lines available

References

• Original: J:88276 Kuwahara K, et al., Germinal center-associated nuclear protein contributes to affinity maturation of B cell antigen receptor in T cell-dependent responses. Proc Natl Acad Sci U S A. 2004 Jan 27;101(4):1010-5
• All: 7 reference(s)