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Phenotypes Associated with This Genotype
Genotype
MGI:3582190
Allelic
Composition
Lmbr1tm1Kng/Del(5D5Mit73-D5Mit351)5Jcs
Genetic
Background
mixed
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(5D5Mit73-D5Mit351)5Jcs mutation (0 available); any Del(5D5Mit73-D5Mit351)5Jcs mutation (0 available)
Lmbr1tm1Kng mutation (0 available); any Lmbr1 mutation (32 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• fewer than expected mutants are present at weaning

limbs/digits/tail
• severe coalitions or reductions of the distal wrist bones involving distal carpal 2, 3 and/or the central as well as other distal carpals are seen in all mutants
• coalitions or reductions of the proximal wrist bones were seen in 36 out of 38 mutants
• 55% of mutants had fewer than 5 digits with one third of these having only 3 digits
• in forelimbs with severely affected wrists the distal ends of the radius and ulna are sometimes narrow and the junction of the radius and ulna is disorganized
• in forelimbs with severely affected wrists the distal ends of the radius and ulna are sometimes narrow and the junction of the radius and ulna is disorganized

growth/size/body

skeleton
• severe coalitions or reductions of the distal wrist bones involving distal carpal 2, 3 and/or the central as well as other distal carpals are seen in all mutants
• coalitions or reductions of the proximal wrist bones were seen in 36 out of 38 mutants
• in forelimbs with severely affected wrists the distal ends of the radius and ulna are sometimes narrow and the junction of the radius and ulna is disorganized
• in forelimbs with severely affected wrists the distal ends of the radius and ulna are sometimes narrow and the junction of the radius and ulna is disorganized


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
01/20/2026
MGI 6.24
The Jackson Laboratory