Phenotypes Associated with This Genotype

Genotype
MGI:3580503

• Allelic Composition: Lhx1^tm2.1Bhr/Lhx1^tm1Tmj; Tg(Rarb-cre)1Bhr/0
• Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:98831 )

• died within the first day of birth

renal/urinary system

absent renal glomerulus ( J:98831 )

• absent glomeruli and their associated tubules in neonates

abnormal kidney development ( J:98831 )

• nephron development was arrested at the stage of the renal vesicle

abnormal kidney medulla development ( J:98831 )

• medulla was not correctly formed in neonates

small metanephros ( J:98831 )

• neonates had small metanephroi without nephrons but with normal ureters and normal reproductive tracts

renal hypoplasia ( J:98831 )

absent nephron ( J:98831 )

• neonates had small metanephroi with no nephrons

abnormal urinary bladder morphology ( J:98831 )

• shrunken bladder with no urine