Phenotypes Associated with This Genotype

Genotype
MGI:3580109

• Allelic Composition: Emx2^tm1Sia/Emx2^tm1Sia; Pax6^Sey/Pax6^Sey
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal brain morphology ( J:98539 )

• an amorphous structure was present where normally the thalamus/pretectum develops at E12.5

• the supraopto-paraventricular area was lost at E12.5

absent choroid plexus ( J:98539 )

• choroid plexus was never apparent at E12.5

abnormal brain commissure morphology ( J:98539 )

• the commissural plate was caudally expanded

abnormal tectum morphology ( J:98539 )

• mirror image duplication of tectum at E18.5, however duplication of the cerebellum or tegmentum did not occur

abnormal pretectal region morphology ( J:98539 )

• both the non-commissure region and the commissure region of the pretectum were absent at E12.5

abnormal thalamus morphology ( J:98539 )

• prethalamus and thalamus were not apparent at E12.5

• zona limitans intrathalamica was never formed

absent diencephalon ( J:98539 )

• diencephalic structures were not apparent at E12.5

abnormal telencephalon morphology ( J:98539 )

• the choroidal roof at the telencephalic level did not develop

abnormal Ammon gyrus morphology ( J:98539 )

• Ammon's horn did not develop at E12.5

absent hippocampus ( J:98539 )

• prospective hippocampus was absent at E12.5

abnormal cerebral cortex morphology ( J:98539 )

• greatly reduced pallium at E18.5 that was lost in the medial portion, greatly reduced but present neopallium at E12.5 and absent cortical hem at E12.5

abnormal embryonic/fetal subventricular zone morphology ( J:98539 )

• hyperplastic ganglionic eminences