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Phenotypes Associated with This Genotype
Genotype
MGI:3580073
Allelic
Composition
Nf1tm1Tyj/Nf1+
Trp53tm1Tyj/Trp53+
Genetic
Background
involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nf1tm1Tyj mutation (3 available); any Nf1 mutation (75 available)
Trp53tm1Tyj mutation (9 available); any Trp53 mutation (147 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• develop in cis-double heterozygotes, usually correlated with loss of one chromosome

mortality/aging
• cis-double heterozygotes die by 5 months of age and trans-double heterozygotes survive to the average age of 10 months

tumorigenesis
• cis-double heterozygotes exhibit greater incidence of tumors than trans-double heterozygotes
• developed in both cis- and trans-double heterozygotes
• sarcomas in trans-double heterozygotes were similar to those found in mice with either single mutation and were usually correlated with loss of one chromosome
• develop in cis-double heterozygotes, usually correlated with loss of one chromosome

Mouse Models of Human Disease
OMIM ID Ref(s)
Neurofibromatosis, Type I; NF1 162200 J:58876


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory