Mouse Genome Informatics
cx
    Nf1tm1Tyj/Nf1+
Trp53tm1Tyj/Trp53+

involves: 129/Sv * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• cis-double heterozygotes die by 5 months of age and trans-double heterozygotes survive to the average age of 10 months

tumorigenesis
• cis-double heterozygotes exhibit greater incidence of tumors than trans-double heterozygotes
• developed in both cis- and trans-double heterozygotes
• sarcomas in trans-double heterozygotes were similar to those found in mice with either single mutation and were usually correlated with loss of one chromosome
• develop in cis-double heterozygotes, usually correlated with loss of one chromosome

Mouse Models of Human Disease
OMIM IDRef(s)
Neurofibromatosis, Type I; NF1 162200 J:58876