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Phenotypes Associated with This Genotype
Genotype
MGI:3580069
Allelic
Composition
Nf1tm1Tyj/Nf1+
Trp53tm1Brd/Trp53+
Genetic
Background
involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nf1tm1Tyj mutation (3 available); any Nf1 mutation (85 available)
Trp53tm1Brd mutation (6 available); any Trp53 mutation (145 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
muscle
• developed in cis-double heterozygotes
• developed in cis-double heterozygotes

nervous system
• developed in cis-double heterozygotes
• developed in cis-double heterozygotes

mortality/aging
• cis-double heterozygotes died at 15 weeks and trans-double heterozygotes died at 25 weeks

neoplasm
• developed in cis-double heterozygotes
• developed in cis-double heterozygotes
• developed in cis-double heterozygotes
• developed in cis-double heterozygotes
• developed in cis-double heterozygotes
• both cis- and trans-double heterozygotes developed sarcomas
• developed in cis-double heterozygotes
• developed in cis-double heterozygotes
• developed in cis-double heterozygotes

integument
• developed in cis-double heterozygotes

Mouse Models of Human Disease
OMIM ID Ref(s)
Neurofibromatosis, Type I; NF1 162200 J:58877


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory