Mouse Genome Informatics
cx
    Nf1tm1Tyj/Nf1+
Trp53tm1Brd/Trp53+

involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• cis-double heterozygotes died at 15 weeks and trans-double heterozygotes died at 25 weeks

tumorigenesis
• developed in cis-double heterozygotes
• developed in cis-double heterozygotes
• developed in cis-double heterozygotes
• developed in cis-double heterozygotes
• developed in cis-double heterozygotes
• both cis- and trans-double heterozygotes developed sarcomas
• developed in cis-double heterozygotes
• developed in cis-double heterozygotes
• developed in cis-double heterozygotes

integument
• developed in cis-double heterozygotes

Mouse Models of Human Disease
OMIM IDRef(s)
Neurofibromatosis, Type I; NF1 162200 J:58877