About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3580069
Allelic
Composition
Nf1tm1Tyj/Nf1+
Trp53tm1Brd/Trp53+
Genetic
Background
involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nf1tm1Tyj mutation (3 available); any Nf1 mutation (24 available)
Trp53tm1Brd mutation (5 available); any Trp53 mutation (142 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• cis-double heterozygotes died at 15 weeks and trans-double heterozygotes died at 25 weeks (J:58877)
• cis-double heterozygotes died at 15 weeks and trans-double heterozygotes died at 25 weeks (J:58877)

tumorigenesis
• developed in cis-double heterozygotes (J:58877)
• developed in cis-double heterozygotes (J:58877)
• developed in cis-double heterozygotes (J:58877)
• developed in cis-double heterozygotes (J:58877)
• developed in cis-double heterozygotes (J:58877)
• developed in cis-double heterozygotes (J:58877)
• developed in cis-double heterozygotes (J:58877)
• developed in cis-double heterozygotes (J:58877)
• developed in cis-double heterozygotes (J:58877)
• developed in cis-double heterozygotes (J:58877)
• both cis- and trans-double heterozygotes developed sarcomas (J:58877)
• both cis- and trans-double heterozygotes developed sarcomas (J:58877)
• developed in cis-double heterozygotes (J:58877)
• developed in cis-double heterozygotes (J:58877)
• developed in cis-double heterozygotes (J:58877)
• developed in cis-double heterozygotes (J:58877)
• developed in cis-double heterozygotes (J:58877)
• developed in cis-double heterozygotes (J:58877)

integument
• developed in cis-double heterozygotes (J:58877)
• developed in cis-double heterozygotes (J:58877)

Mouse Models of Human Disease
OMIM ID Ref(s)
Neurofibromatosis, Type I; NF1 162200 J:58877


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
01/26/2016
MGI 6.02
The Jackson Laboratory