Phenotypes Associated with This Genotype

Genotype
MGI:3578520

• Allelic Composition: Dicer1^tm1Mmk/Dicer1^tm1Mmk; Tg(Lck-cre)1Cwi/0
• Genetic Background: involves: C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased gamma-delta T cell number ( J:98192 )

• unusually high percentage of thymocytes expressed TCR gamma-delta and gamma-delta cells were prevalent in the double negative compartment and decreased numbers of alpha-beta T cells

decreased T cell number ( J:98192 )

• decreased numbers of alpha-beta T cells

decreased thymocyte number ( J:98192 )

• cell numbers in thymi were reduced nearly 10-fold relative to controls, however there were normal numbers of double negative cells in thym

• increased percentage (43% versus 11% of wildtype at 6 hours and 68% versus 30% at 24 hours) of dying thymocytes when grown in vitro

hematopoietic system

increased gamma-delta T cell number ( J:98192 )

• unusually high percentage of thymocytes expressed TCR gamma-delta and gamma-delta cells were prevalent in the double negative compartment and decreased numbers of alpha-beta T cells

decreased T cell number ( J:98192 )

• decreased numbers of alpha-beta T cells

decreased thymocyte number ( J:98192 )

• cell numbers in thymi were reduced nearly 10-fold relative to controls, however there were normal numbers of double negative cells in thym

• increased percentage (43% versus 11% of wildtype at 6 hours and 68% versus 30% at 24 hours) of dying thymocytes when grown in vitro

endocrine/exocrine glands

decreased thymocyte number ( J:98192 )

• cell numbers in thymi were reduced nearly 10-fold relative to controls, however there were normal numbers of double negative cells in thym

• increased percentage (43% versus 11% of wildtype at 6 hours and 68% versus 30% at 24 hours) of dying thymocytes when grown in vitro