Phenotypes Associated with This Genotype

Genotype
MGI:3577619

• Allelic Composition: Pcgf2^tm1Hko/Pcgf2^tm1Hko; Bmi1^tm1Brn/Bmi1^tm1Brn
• Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:68216 )

• double homozygotes die around E9.5

cardiovascular system

abnormal dorsal aorta morphology ( J:68216 )

• dorsal aorta is expanded in the caudal region

embryo

abnormal first pharyngeal arch morphology ( J:68216 )

• first branchial arches were poorly developed

abnormal second pharyngeal arch morphology ( J:68216 )

• second branchial arches were poorly developed

embryonic growth arrest ( J:68216 )

• development was normal at E8.5 but mice were severely growth retarded at E9.5

abnormal somatic mesoderm morphology ( J:68216 )

• somatic mesoderm was appropriately segmented but irregularly aligned

abnormal neural tube morphology ( J:68216 )

• neural tube is small

• cell to cell adhesion is impaired in the neural tube

abnormal notochord morphology ( J:68216 )

• fusion with hindgut endoderm seen

small notochord ( J:68216 )

• reduced

split notochord ( J:68216 )

• bifurcated

abnormal somite development ( J:68216 )

• 18 as opposed to the normal 24 somites at E9.5

abnormal tail bud morphology ( J:68216 )

• distal tip of the tail bud is shrunken

nervous system

increased neural tube apoptosis ( J:68216 )

• apoptosis is seen in the neural tube

abnormal neural tube morphology ( J:68216 )

• neural tube is small

• cell to cell adhesion is impaired in the neural tube

abnormal brain morphology ( J:68216 )

hindbrain hypoplasia ( J:68216 )

• hindbrain is underdeveloped

skeleton

abnormal cervical atlas morphology ( J:68216 )

• atlas resembles the third cervical vertebra

cervical vertebral transformation ( J:68216 )

• atlas resembles the third cervical vertebra

craniofacial

abnormal first pharyngeal arch morphology ( J:68216 )

• first branchial arches were poorly developed

abnormal second pharyngeal arch morphology ( J:68216 )

• second branchial arches were poorly developed

limbs/digits/tail

abnormal tail bud morphology ( J:68216 )

• distal tip of the tail bud is shrunken

vision/eye

abnormal optic eminence morphology ( J:68216 )

• optic eminence was obscure

cellular

increased neural tube apoptosis ( J:68216 )

• apoptosis is seen in the neural tube