Phenotypes Associated with This Genotype

Genotype
MGI:3574392

• Allelic Composition: Dcn^tm1Ioz/Dcn^tm1Ioz; Trp53^tm1Brd/Trp53^tm1Brd
• Genetic Background: involves: 129/Sv * Black Swiss * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased tumor-free survival time ( J:53511 )

• by ~4 months of age, ~50% of double homozygotes die or need to be sacrificed because of ill health

• by 5 months, ~90% of double homozygotes succumb to tumor growth

neoplasm

increased tumor incidence ( J:53511 )

• double homozygotes are predisposed to an accelerated mortality due to increased tumorigenesis, with no differences between male and female occurrence

• double mutants show a significant homogeneity in tumor spectrum and do not exhibit multiple tumors

increased T cell derived lymphoma incidence ( J:53511 )

• the majority of tumors are high-grade lymphomas arising from the transformation of immature thymocytes

• tumor cells are highly invasive and infiltrate the soft tissues of mediastinum, the salivary glands, the periaortic spaces, the pericardium, and the bronchial wall

increased hemangiosarcoma incidence ( J:53511 )

• only one double homozygote developed a high-grade hemangiosarcoma in the submandibular region

immune system

enlarged thymus ( J:53511 )

• ~5% of double homozygotes have a significantly enlarged thymus, in the absence of overt tumors

thymus hyperplasia ( J:53511 )

• ~5% of double homozygotes display no overt neoplasms but show thymic hyperplasia with foci of atypical lymphocytes infiltrating the mediastinal soft tissues and signs of early-invading malignant lymphomas

increased T cell derived lymphoma incidence ( J:53511 )

• the majority of tumors are high-grade lymphomas arising from the transformation of immature thymocytes

• tumor cells are highly invasive and infiltrate the soft tissues of mediastinum, the salivary glands, the periaortic spaces, the pericardium, and the bronchial wall

respiratory system

respiratory distress ( J:53511 )

• double homozygotes with thymic lymphomas die of pericardial compression or respiratory distress

hematopoietic system

enlarged thymus ( J:53511 )

• ~5% of double homozygotes have a significantly enlarged thymus, in the absence of overt tumors

thymus hyperplasia ( J:53511 )

• ~5% of double homozygotes display no overt neoplasms but show thymic hyperplasia with foci of atypical lymphocytes infiltrating the mediastinal soft tissues and signs of early-invading malignant lymphomas

increased T cell derived lymphoma incidence ( J:53511 )

• the majority of tumors are high-grade lymphomas arising from the transformation of immature thymocytes

• tumor cells are highly invasive and infiltrate the soft tissues of mediastinum, the salivary glands, the periaortic spaces, the pericardium, and the bronchial wall

endocrine/exocrine glands

enlarged thymus ( J:53511 )

• ~5% of double homozygotes have a significantly enlarged thymus, in the absence of overt tumors

thymus hyperplasia ( J:53511 )

• ~5% of double homozygotes display no overt neoplasms but show thymic hyperplasia with foci of atypical lymphocytes infiltrating the mediastinal soft tissues and signs of early-invading malignant lymphomas

increased T cell derived lymphoma incidence ( J:53511 )

• the majority of tumors are high-grade lymphomas arising from the transformation of immature thymocytes

• tumor cells are highly invasive and infiltrate the soft tissues of mediastinum, the salivary glands, the periaortic spaces, the pericardium, and the bronchial wall