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Phenotypes Associated with This Genotype
Genotype
MGI:3530450
Allelic
Composition
Nrg1tm2Zhou/Nrg1+
Genetic
Background
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nrg1tm2Zhou mutation (0 available); any Nrg1 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• animals are significantly more active than controls in an open field test and in a four arm-cross maze test (J:81106)
• treatment of mice with 1mg/kg clozapine reversed the phenotype (J:81106)
• animals are significantly more active than controls in an open field test and in a four arm-cross maze test (J:81106)
• treatment of mice with 1mg/kg clozapine reversed the phenotype (J:81106)

nervous system
• impairment was seen, while normal acoustic startle response was also observed (J:81106)
• impairment was seen, while normal acoustic startle response was also observed (J:81106)

Mouse Models of Human Disease
OMIM ID Ref(s)
Schizophrenia; SCZD 181500 J:81106


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory