Phenotypes Associated with This Genotype

Genotype
MGI:3527142

• Allelic Composition: Plaur^tm1Mlg/Plaur^tm1Mlg
• Genetic Background: B6.Cg-Plaur^tm1Mlg

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:81735 )

N • in the open-field test, homozygotes display normal generalized motor activity relative to wild-type

increased susceptibility to pharmacologically induced seizures ( J:81735 )

• homozygotes exhibit increased susceptibility to pentylenetretrazol (PTZ)-induced seizures, displaying tonic extension and reduced latency time relative to wild-type

decreased exploration in new environment ( J:81735 )

• in the open-field paradigm, wild-type mice occupy the margin of the arena for 66% of the time and the center for 34%, whereas mutants occupy the margin area for 76% of the time and the center for 24%, indicating decreased exploratory behavior

increased anxiety-related response ( J:81735 )

• in the light-dark avoidance test, wild-type mice spend ~50% of the 10 min session exploring the lit side of the chamber whereas mutants occupy the lit side for only 25% of the time, preferring the less aversive, dark area

• in the elevated plus maze, wild-type mice spend ~25-30% of the time in the open arms, whereas mutants spend <5% of the time in the open arms; mutants spend >75% of the time in the closed arms, and ~25% of the time in the center of the maze

myoclonus ( J:81735 )

• ~6% of homozygotes display a novel pattern of spontaneous myoclonic seizures with abnormal bilaterally synchronous interictal discharges during waking behavior; such seizures are occasionally lethal

muscle

myoclonus ( J:81735 )

• ~6% of homozygotes display a novel pattern of spontaneous myoclonic seizures with abnormal bilaterally synchronous interictal discharges during waking behavior; such seizures are occasionally lethal

nervous system

increased susceptibility to pharmacologically induced seizures ( J:81735 )

• homozygotes exhibit increased susceptibility to pentylenetretrazol (PTZ)-induced seizures, displaying tonic extension and reduced latency time relative to wild-type

myoclonus ( J:81735 )

• ~6% of homozygotes display a novel pattern of spontaneous myoclonic seizures with abnormal bilaterally synchronous interictal discharges during waking behavior; such seizures are occasionally lethal

abnormal neuronal migration ( J:69135 )

• at at E16.5 and P0, homozygotes display diminished levels of hepatocyte growth factor/scatter factor (HGF/SF), reduced scatter activity in the forebrain, and impaired migration of interneurons from the ganglionic eminence to the cerebral cortex

abnormal brain interneuron morphology ( J:69135 )

• homozygotes display a 50-65% reduction in the number of GABAergic interneurons in frontal and parietal neocortices at E16.5 and P0

abnormal cerebral cortex morphology ( J:69135 )

• in homozygotes, the cortical plate is well-laminated; however, the overall packing density and thickness of the cerebral wall is greater in mutants compared to wild-type

loss of cortex neurons ( J:81735 )

• adult homozygotes show a 50% deficit in GABA+ cells in both anterior cingulate and parietal cortical regions, with almost complete loss of the parvalbumin subtype

• notably, interneuron numbers in piriform and visual cortical areas remain unaffected

loss of GABAergic neurons ( J:81735 )

• adult homozygotes exhibit a significant reduction of GABAergic neurons in the parietal cortex, with regional variation in the reduction of GABA+ cells between frontal and visual cortices

cellular

abnormal neuronal migration ( J:69135 )

• at at E16.5 and P0, homozygotes display diminished levels of hepatocyte growth factor/scatter factor (HGF/SF), reduced scatter activity in the forebrain, and impaired migration of interneurons from the ganglionic eminence to the cerebral cortex