Plaur^tm1Mlg
Targeted Allele Detail

Summary

• Symbol: Plaur^tm1Mlg
• Name: plasminogen activator, urokinase receptor; targeted mutation 1, Richard C Mulligan
• MGI ID: MGI:1934210
• Synonyms: u-PAR -, uPAR^-
• Gene: Plaur Location: Chr7:24161909-24175393 bp, + strand Genetic Position: Chr7, 10.92 cM, cytoband A3
• Alliance: Plaur^tm1Mlg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:31253
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK- neomycin cassette replaced exons 2-5, resulting in the inactivation of both splice variants of the gene. The absence of protein was verified in an ELISA assay on culture from primary embryonic fibroblast cells. (J:31253)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Plaur Mutation: 18 strains or lines available

References

• Original: J:31253 Dewerchin M, et al., Generation and characterization of urokinase receptor-deficient mice. J Clin Invest. 1996 Feb 1;97(3):870-8
• All: 41 reference(s)