Analysis Tools
hematopoietic system
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• B cell precursors are found in the blood
• a large number of the B cell precursors die before they can complete the differentiation process
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• the total number of mature B cells in the spleen is reduced to about 65% of wild-type
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• the peritoneal B1 cell population is reduced in young and old mutants
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• the peritoneal B2 cell population is reduced only in older mutants
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• a greater than 20-fold reduction in the number of T cell independent antigen-specific plasma cells in the bone marrow is seen after immunization with Ficoll
• the number of antibody-secreting cells is reduced in the bone marrow and increased in the spleen 9 days after immunization, however long-term antibody production is not impaired
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• basal levels of serum IG of all isotypes are reduced
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immune system
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• B cell follicles are more dispersed, frequently occur deep in the lamina propria, and some have enlarged T cell zones
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• B cell precursors are found in the blood
• a large number of the B cell precursors die before they can complete the differentiation process
|
|
• the total number of mature B cells in the spleen is reduced to about 65% of wild-type
|
|
• the peritoneal B1 cell population is reduced in young and old mutants
|
|
• the peritoneal B2 cell population is reduced only in older mutants
|
|
• a greater than 20-fold reduction in the number of T cell independent antigen-specific plasma cells in the bone marrow is seen after immunization with Ficoll
• the number of antibody-secreting cells is reduced in the bone marrow and increased in the spleen 9 days after immunization, however long-term antibody production is not impaired
|
|
• basal levels of serum IG of all isotypes are reduced
|
digestive/alimentary system
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• B cell follicles are more dispersed, frequently occur deep in the lamina propria, and some have enlarged T cell zones
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