Phenotypes for Disp1 Shh MGI:3513050 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Disp1^tm2.1Amc/Disp1^tm2.1Amc Shh^tm1Amc/Shh⁺
Genetic Background	involves: 129/Sv * C57BL/6J * SWR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Disp1^tm2.1Amc mutation (0 available); any Disp1 mutation (61 available)
Shh^tm1Amc mutation (1 available); any Shh mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal neuron differentiation ( J:94270 )

• the reduction of pMN and pV2 progenitors results in a decrease in motorneuron precursors that are also abnormally positioned at the ventral midline

absent floor plate ( J:94270 )

• the floor plate is absent and the ventral midline has reduced numbers of the ventral most neural progenitors

embryo

absent floor plate ( J:94270 )

• the floor plate is absent and the ventral midline has reduced numbers of the ventral most neural progenitors

cellular

abnormal neuron differentiation ( J:94270 )

• the reduction of pMN and pV2 progenitors results in a decrease in motorneuron precursors that are also abnormally positioned at the ventral midline

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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