Phenotypes Associated with This Genotype

Genotype
MGI:3511241

• Allelic Composition: Ly6a^{tm2(RUNX1)Grau}/Ly6a⁺
• Genetic Background: involves: 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Morophologic analysis of myeloproliferation disorder in Ly6a^{tm2(RUNX1)Grau}/Ly6a⁺ mice

neoplasm

increased squamous cell carcinoma incidence ( J:93408 )

• skin lesions progressed to squamous cell carcinomas in 3 of 23 mutants by 1 year of age

hematopoietic system

enlarged spleen ( J:93408 )

• at 9-12 months of age splenomegaly is seen

absent common myeloid progenitor cells ( J:93408 )

• at 5-8 weeks of age there is a slight but significant decrease in myeloid progenitors in the bone marrow

myeloid hyperplasia ( J:93408 )

• at 9-12 months of age bone marrow myeloid hyperplasia is seen

extramedullary hematopoiesis ( J:93408 )

• at 9-12 months of age extramedullary hematopoiesis is seen

increased erythroid progenitor cell number ( J:93408 )

• at 9-12 months of age an increase in peripheral blood reticulocytes is seen

polychromatophilia ( J:93408 )

• polychromasia in peripheral blood

increased leukocyte cell number ( J:93408 )

• at 5-8 weeks of age there is a slight but significant increase in WBC count

increased neutrophil cell number ( J:93408 )

• at 9-12 months of age an increase in peripheral blood neutrophils is seen

abnormal spleen B cell follicle morphology ( J:93408 )

• extramedullary hematopoiesis disrupts the follicular architecture of the spleen

immune system

enlarged spleen ( J:93408 )

• at 9-12 months of age splenomegaly is seen

myeloid hyperplasia ( J:93408 )

• at 9-12 months of age bone marrow myeloid hyperplasia is seen

increased leukocyte cell number ( J:93408 )

• at 5-8 weeks of age there is a slight but significant increase in WBC count

increased neutrophil cell number ( J:93408 )

• at 9-12 months of age an increase in peripheral blood neutrophils is seen

abnormal spleen B cell follicle morphology ( J:93408 )

• extramedullary hematopoiesis disrupts the follicular architecture of the spleen

integument

hyperkeratosis ( J:93408 )

• after 4 weeks of age hyperkeratosis is seen

epidermal hyperplasia ( J:93408 )

• at 4 weeks of age epidermal hyperplasia is seen

spontaneous skin ulceration ( J:93408 )

• after 4 weeks of age skin ulcerations appear

growth/size/body

enlarged spleen ( J:93408 )

• at 9-12 months of age splenomegaly is seen