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Phenotype Image Detail
Image
Caption Morphologic analysis of MPD. Peripheral blood and bone marrow slides show evidence of myeloid hyperplasia with loss of erythroid and lymphoid precursors in the bone marrow and polychromasia in peripheral blood of Ly6atm2(RUNX1)Grau/Ly6a+ mice compared with wild type littermates. In the spleen, increased extramedullary hematopoiesis disrupts the follicular architecture.
Copyright This image is from Fenske TS, Proc Natl Acad Sci U S A 2004 Nov 19;101(42):15184-9. Copyright 2004 National Academy of Sciences, U.S.A. J:93408
Associated
Alleles
Symbol Name
Ly6atm2(RUNX1)Grau lymphocyte antigen 6 family member A; targeted mutation 2, Timothy A Graubert
Associated
Genotypes
Allelic Composition Genetic Background
Ly6atm2(RUNX1)Grau/Ly6a+ involves: 129X1/SvJ * C57BL/6J
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory