Mouse Genome Informatics
cx
     Cd40tm1Kik/Cd40tm1Kik
Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix
involves: 129 * 129P2/OlaHsd * BALB/c
Key:
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
increased transitional stage B cell number ( J:138560 )
• double mutants exhibit an increase in peripheral B cell populations compared to Cd40 single homozygotes
increased follicular B cell number ( J:138560 )
• double mutants exhibit an increase in peripheral B cell populations compared to Cd40 single homozygotes
increased marginal zone B cell number ( J:138560 )
• double mutants exhibit an increase in peripheral B cell populations compared to Cd40 single homozygotes
enlarged spleen ( J:93923 )
• enlargement of the spleen is reduced compared to Traf3ip2 single homozygotes
• immunoglobulin levels are normal unlike in Traf3ip2 single homozygotes
abnormal B cell physiology ( J:138560 )
• Tnfsf13b (BAFF) stimulation results in enhanced B cell survival compared to single Cd40 mutants

immune system
immune system phenotype ( J:138560 )
N
• double mutants do not exhibit production of anti-SSA/Ro and anti-SSB/La autoantibodies in response to recombinant SSA/Ro and SSB/La antigens, as seen in Traf3ip2 single homozygotes
increased transitional stage B cell number ( J:138560 )
• double mutants exhibit an increase in peripheral B cell populations compared to Cd40 single homozygotes
increased follicular B cell number ( J:138560 )
• double mutants exhibit an increase in peripheral B cell populations compared to Cd40 single homozygotes
increased marginal zone B cell number ( J:138560 )
• double mutants exhibit an increase in peripheral B cell populations compared to Cd40 single homozygotes
enlarged spleen ( J:93923 )
• enlargement of the spleen is reduced compared to Traf3ip2 single homozygotes
• immunoglobulin levels are normal unlike in Traf3ip2 single homozygotes
abnormal B cell physiology ( J:138560 )
• Tnfsf13b (BAFF) stimulation results in enhanced B cell survival compared to single Cd40 mutants
enlarged lymph nodes ( J:93923 )
• enlargement of the lymph nodes is reduced compared to Traf3ip2 single homozygotes

Mouse Models of Human Disease
 OMIM IDRef(s)
NOT Immunodeficiency with Hyper-IgM, Type 1; HIGM1 308230 J:93923