hematopoietic system
• enlargement of the spleen is reduced compared to Traf3ip2 single homozygotes
• immunoglobulin levels are normal unlike in Traf3ip2 single homozygotes
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• double mutants exhibit an increase in peripheral B cell populations compared to Cd40 single homozygotes
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• double mutants exhibit an increase in peripheral B cell populations compared to Cd40 single homozygotes
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• double mutants exhibit an increase in peripheral B cell populations compared to Cd40 single homozygotes
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• Tnfsf13b (BAFF) stimulation results in enhanced B cell survival compared to single Cd40 mutants
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immune system
N |
• double mutants do not exhibit production of anti-SSA/Ro and anti-SSB/La autoantibodies in response to recombinant SSA/Ro and SSB/La antigens, as seen in Traf3ip2 single homozygotes
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• enlargement of the spleen is reduced compared to Traf3ip2 single homozygotes
• immunoglobulin levels are normal unlike in Traf3ip2 single homozygotes
|
• double mutants exhibit an increase in peripheral B cell populations compared to Cd40 single homozygotes
|
• double mutants exhibit an increase in peripheral B cell populations compared to Cd40 single homozygotes
|
• double mutants exhibit an increase in peripheral B cell populations compared to Cd40 single homozygotes
|
• Tnfsf13b (BAFF) stimulation results in enhanced B cell survival compared to single Cd40 mutants
|
• enlargement of the lymph nodes is reduced compared to Traf3ip2 single homozygotes
|
growth/size/body
• enlargement of the spleen is reduced compared to Traf3ip2 single homozygotes
• immunoglobulin levels are normal unlike in Traf3ip2 single homozygotes
|