Phenotypes Associated with This Genotype

Genotype
MGI:3056465

• Allelic Composition: Rbpj^tm1Kyo/Rbpj^tm1Hon; Tg(Tek-cre)12Flv/0
• Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal dorsal aorta morphology ( J:93125 )

• the diameter of the dorsal aorta is reduced at E9.5

abnormal vascular regression ( J:93125 )

• at E9.5 PECAM-1 staining revealed a complete lack of vascular remodeling

abnormal anterior cardinal vein morphology ( J:93125 )

• the distal outflow tract is connected to the anterior cardinal vein by an anastamoses

abnormal common cardinal vein morphology ( J:93125 )

• some embryos also have more caudal fusions of the dorsal aorta to the common cardinal vein

absent vitelline blood vessels ( J:93125 )

• an avascular yolk is seen at E9.5

arteriovenous malformation ( J:93125 )

pericardial effusion ( J:93125 )

• pericardial effusion is seen at E9.5

embryo

absent vitelline blood vessels ( J:93125 )

• an avascular yolk is seen at E9.5

embryonic growth retardation ( J:93125 )

• embryonic growth retardation is seen at E9.5

growth/size/body

embryonic growth retardation ( J:93125 )

• embryonic growth retardation is seen at E9.5

homeostasis/metabolism

pericardial effusion ( J:93125 )

• pericardial effusion is seen at E9.5

cellular

abnormal vascular regression ( J:93125 )

• at E9.5 PECAM-1 staining revealed a complete lack of vascular remodeling