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Phenotypes Associated with This Genotype
Genotype
MGI:3056102
Allelic
Composition
Timp3tm1Rkho/Timp3tm1Rkho
Genetic
Background
FVB.129-Timp3tm1Rkho
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Timp3tm1Rkho mutation (0 available); any Timp3 mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• female homozygotes exhibit excessive and unscheduled epithelial apoptosis in the involuting mammary gland
• in mutants, epithelial cell shedding and apoptosis occur on the first day of involution (1di) versus 3di and 4di in wild-type
• epithelial cell death leads to early loss of beta-casein expression, rapid lobulo-alveolar collapse and early adipose differentiation and reconstitution

respiratory system
N
• 6-8 week-old primiparous mutant females display no signs of abnormal lung function, which only becomes apparent after 1 year of age

endocrine/exocrine glands
• 6-8-week-old primiparous mutant females show an early loss of milk production, cell shedding, and a rapid loss of epithelial compartment during post-lactational involution
• mutant dams show no differences in litter size or pup weight gain during nursing relative to wild-type
• however, mutant dams are unable to reestablish lactation after a 2-day cessation of suckling during mammary gland involution

integument
• 6-8-week-old primiparous mutant females show an early loss of milk production, cell shedding, and a rapid loss of epithelial compartment during post-lactational involution
• mutant dams show no differences in litter size or pup weight gain during nursing relative to wild-type
• however, mutant dams are unable to reestablish lactation after a 2-day cessation of suckling during mammary gland involution


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/28/2024
MGI 6.13
The Jackson Laboratory