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Phenotypes Associated with This Genotype
Genotype
MGI:3051600
Allelic
Composition
Agtr1atm1Unc/Agtr1atm1Unc
Agtr1btm1Cof/Agtr1btm1Cof
Hprt1tm1(Ggt1-Agtr1)Cof/Y
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agtr1atm1Unc mutation (1 available); any Agtr1a mutation (38 available)
Agtr1btm1Cof mutation (0 available); any Agtr1b mutation (18 available)
Hprt1tm1(Ggt1-Agtr1)Cof mutation (0 available); any Hprt1 mutation (1280 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• renin levels reduced by 70% from levels found in mice homozygous for both Agtr1tm1Unc and Agtr1btm1Cof
• renin levels essentially normal

renal/urinary system
• greatly reduced number and size of glomerular and cortical cysts relative to the condition in mice homozygous for both Agtr1tm1Unc and Agtr1btm1Cof
• architecture of the renal cortex is preserved

growth/size/body
• greatly reduced number and size of glomerular and cortical cysts relative to the condition in mice homozygous for both Agtr1tm1Unc and Agtr1btm1Cof
• architecture of the renal cortex is preserved


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory