Phenotypes Associated with This Genotype

Genotype
MGI:3051567

• Allelic Composition: Pim1^tm1Pwl/Pim1^tm1Pwl; Pim2^tm1Brn/Pim2^tm1Brn; Pim3^tm1Brn/Pim3^tm1Brn
• Genetic Background: involves: 129P/Ola * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased birth body size ( J:91592 )

♀ • neonates are smaller compared to wild-type and littermates that are not homozygous for at least one of the loci

postnatal growth retardation ( J:91592 )

♀ • mutants are about 30% smaller compared to wild-type and littermates that are not homozygous at at least one of the loci

♀ • all organs, except for the thymus, are decreased in size in proportion to the reduced body size as a result of a decrease in cell number

hematopoietic system

decreased B cell proliferation ( J:91592 )

♀ • B cell proliferation in response to IL-7 is significantly impaired in the bone marrow

decreased T cell proliferation ( J:91592 )

♀ • T cell proliferation is reduced in response to suboptimal levels of alphaCD3 and IL2

increased early pro-B cell number ( J:91592 )

♀ • the fraction of pre-pro-B cells is increased in the bone marrow

decreased pro-B cell number ( J:91592 )

♀ • the fraction of late pro-B cells is slightly decreased

decreased megakaryocyte cell number ( J:91592 )

♀ • fewer and hypoproliferative megakaryocytes are seen in spleen sections

abnormal proerythroblast morphology ( J:91592 )

♀ • the erythroid progenitor fraction in the spleen is increased

increased erythrocyte cell number ( J:91592 )

♀ • a slight increase in erythrocyte numbers is seen without an increase in hematocrit

♀ • the number of mature erthrocytes is also increased in the spleen

decreased mean corpuscular volume ( J:91592 )

♀ • mean erythrocyte cell volume is decreased

decreased B cell number ( J:91592 )

♀ • the fraction of splenic B cell is reduced about 25% at 8 weeks but returns to normal by 20 weeks

decreased pre-B cell number ( J:91592 )

♀ • the fraction of pre-B cells especially of late pre-B cells is decreased in the bone marrow

immune system

decreased B cell proliferation ( J:91592 )

♀ • B cell proliferation in response to IL-7 is significantly impaired in the bone marrow

decreased T cell proliferation ( J:91592 )

♀ • T cell proliferation is reduced in response to suboptimal levels of alphaCD3 and IL2

increased early pro-B cell number ( J:91592 )

♀ • the fraction of pre-pro-B cells is increased in the bone marrow

decreased pro-B cell number ( J:91592 )

♀ • the fraction of late pro-B cells is slightly decreased

decreased B cell number ( J:91592 )

♀ • the fraction of splenic B cell is reduced about 25% at 8 weeks but returns to normal by 20 weeks

decreased pre-B cell number ( J:91592 )

♀ • the fraction of pre-B cells especially of late pre-B cells is decreased in the bone marrow

cellular

decreased B cell proliferation ( J:91592 )

♀ • B cell proliferation in response to IL-7 is significantly impaired in the bone marrow

decreased T cell proliferation ( J:91592 )

♀ • T cell proliferation is reduced in response to suboptimal levels of alphaCD3 and IL2