Phenotypes Associated with This Genotype

Genotype
MGI:3050982

• Allelic Composition: Met^tm2Cbm/Met^tm2.1Cbm; Tg(Mx1-cre)1Cgn/?
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

liver/biliary system

microvesicular hepatic steatosis ( J:91484 )

• liver was normal at 3 weeks after transgene induction

• 6 months after transgene induction, liver contained an accumulation of small lipid droplets (microvesicular steatosis) but no fibrosis

impaired liver regeneration ( J:91484 )

• regeneration of the liver after partial hepatectomy is impaired

• growth factors in the blood such as HGF/SF and Il6 peak a little later than in wild-type mice (6-12 hours as opposed to 6 hours postoperatively)

• growth factor levels remain elevated longer (still high at 46 hours postoperative)