Phenotypes Associated with This Genotype

Genotype
MGI:3046406

• Allelic Composition: Tg(IghMyc)22Bri/0; Tg(Igk-V21-Bax)1967Bvn/0
• Genetic Background: involves: C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:89049 )

• 50% of double transgenics die of a lymphoproliferative disorder by 5.5 weeks

neoplasm

increased B cell derived lymphoma incidence ( J:89049 )

• multifocal to coalescent infiltrations of mononuclear cells with large round to polygonal hypochromatic nuclei are seen in the kidneys, spleen, lymph node, liver, ung, heart, thymus, pancreas, and sternal bone marrow

increased plasmacytoma incidence ( J:89049 )

• osteolytic lesions with cheets of pleomorphic plasmacytic cells adjacent to lysed osseous trabeculae are seen

hematopoietic system

enlarged spleen ( J:89049 )

• 4 - 6 week old double transgenic exhibit severe splenomegaly

increased transitional stage B cell number ( J:89049 )

• the number of immature/transitional B cells is increased

immune system

enlarged spleen ( J:89049 )

• 4 - 6 week old double transgenic exhibit severe splenomegaly

increased transitional stage B cell number ( J:89049 )

• the number of immature/transitional B cells is increased

liver/biliary system

abnormal liver morphology ( J:89049 )

• multiple beige nodules up to 2 mm in diameter are seen

growth/size/body

enlarged spleen ( J:89049 )

• 4 - 6 week old double transgenic exhibit severe splenomegaly