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Phenotypes Associated with This Genotype
Genotype
MGI:3044601
Allelic
Composition		 Tg(ACTB-NOTCH1)1Shn/0
Tg(Nes-cre)1Kln/0
Trp53tm1Tyj/Trp53tm1Tyj
Genetic
Background		 involves: 129S2/SvPas * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(ACTB-NOTCH1)1Shn mutation (1 available)
Tg(Nes-cre)1Kln mutation (4 available)
Trp53tm1Tyj mutation (12 available); any Trp53 mutation (237 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, incomplete penetrance ( J:90392 )
• fewer than expected double transgenic homozygous mutants are found due to incomplete penetrance of Trp53tm1Tyj embryonic lethality

cellular
cellular phenotype ( J:90392 )
N
• at E10 - 11.5 no increase in the number of apoptotic cells in the brain is found unlike in double transgenics with wild-type Trp53

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/30/2025
MGI 6.24 		The Jackson Laboratory